“From Cytosine to Uracil: A Deep Dive into Pyrimidine Bases”

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International Chemistry Scientist Awards


Pyrimidine is a fundamental heterocyclic aromatic organic compound composed of a six-membered ring with two nitrogen atoms at positions 1 and 3. It plays a crucial role in the molecular biology of life, forming the structural core of key nucleobases like cytosine (C), thymine (T), and uracil (U)—vital for the composition of DNA and RNA. These pyrimidine derivatives pair with purines in the genetic code, facilitating accurate replication and transcription. Beyond genetics, pyrimidine derivatives serve as vital scaffolds in medicinal chemistry. They are found in numerous therapeutic agents used to treat cancer, viral infections, and inflammatory diseases due to their ability to interact with biological targets. Their versatile chemical reactivity allows for functional modifications, making them valuable in drug development, diagnostics, and biotechnological innovations.


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