"Mastering Grignard Reagents: The Backbone of Organic Synthesis"

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International Chemistry Scientist Awards


Grignard reagents are a class of organomagnesium compounds with the general formula R–Mg–X, where R is an alkyl or aryl group and X is a halogen (typically Cl, Br, or I). Discovered by French chemist Victor Grignard in 1900, these reagents are highly reactive and play a pivotal role in organic synthesis, especially in forming carbon–carbon bonds. They are typically prepared by reacting an alkyl or aryl halide with magnesium metal in an anhydrous ether solvent. Grignard reagents are used to synthesize alcohols, carboxylic acids, and other functional groups by reacting with electrophiles like aldehydes, ketones, esters, and CO₂. Due to their sensitivity to moisture and air, these reagents must be handled under inert conditions. Their versatility makes them invaluable in both academic and industrial organic chemistry.

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