"Bioisosteres: Small Changes, Big Impacts in Drug Design

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Bioisosteres are chemical substituents or groups within a molecule that exhibit similar physical or chemical properties, producing broadly comparable biological effects. They are extensively used in drug design and development to enhance the pharmacological profile, reduce toxicity, or improve metabolic stability of therapeutic compounds. Bioisosteric replacements can optimize molecular interactions with biological targets, leading to the creation of more effective and safer drugs.

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